In the course of their lives, all women must inevitably come to terms with menopause. A phase that unfortunately is the source of additional numerous annoyances, as if women did not have enough during the phase of fertility!
Some of these disorders, such as hot flashes, irritability and slow metabolism, are experienced right away. Others, instead, emerge at a later stage, such as bone or cardiovascular problems.

Our objective and yours is to provide the best possible support. How to achieve this? Is a multi-factor or selective approach for the individual disorder more functional?

Oestrogen and progesterone, the cause behind everything

Let’s start by defining what menopause is, meaning, the physiological condition that coincides with the cessation of ovarian activity, which causes a reduction in oestrogen and, albeit minor, progesterone levels.
Oestrogens are a group of female sex hormones secreted by the ovary that are responsible for stimulating ovulation in women.
Progesterone, on the other hand, is responsible for preparing the female reproductive organs for pregnancy and keeping the uterus in the necessary condition for the development of the embryo.

During menopause, these hormones are in fact no longer necessary, so the female body reduces production. A 35% reduction in oestrogen and 75% reduction in progesterone can be observed between the ages of 30 and 50. (1).
These hormones perform functions not only in the ovary but also on a systemic level: oestrogens, for example, regulate the distribution of body fat  (2), increase the production of HDL (good cholesterol), stimulate lipolysis of muscle and adipose tissue, regulate various brain functions(3) and body temperature (4).

This is the reason for the multiple disorders in menopausal women!

Intervene with a multi-factor approach

To provide the best possible support it is therefore optimal:

  1. To intervene at the root of the problem first of all;
  2. To reduce the most bothersome ailments that afflict a woman at an early stage;
  3. Also to protect against ailments she will encounter later;

It is with these objectives in mind that Naturando developed Donna Sempre Pausa, a food supplement specifically designed for menopausal women.


Its formulation ensures 3 different actions, for a complete intervention:

  • BONE MAINTENANCE: minerals and vitamins such as Magnesium, Calcium and Vitamin D;


What’s more, Donna Sempre Pausa has a high compliance rate amongst women who use it; the treatment requires you to take only 1 tablet per day.


Donna Sempre Pausa was subjected to a double-blind, placebo-controlled clinical trial, available at the following link

The results showed the effectiveness of Donna Sempre Pausa in significantly improving ailments linked to menopause. Ninety-five per cent of the women who were treated with this supplement noticed an improvement in their symptoms; the same improvement perceived by the participants was also observed through objective parameters assessed during a gynaecological examination.

HOT FLASHES: the disturbance most commonly experienced

Hot flashes are by far the most common disturbance in women Sometimes a multi-factor approach works less specifically on a single disorder, which is why it may be useful to combine with a specific product.


Naturando’s proposal is Donna No Vamp, a supplement against menopausal disorders (Sage, Chasteberry), with targeted action against hot flashes (Hops).
This product consists of 100% plant extracts, in drops, so it can be conveniently taken as needed either directly under the tongue or diluted in water on a daily basis.


Is a multi-factor or selective approach for the individual disorder more functional?

While the question might seem complicated, the answer is not. For best results, an integrated approach is optimal: a comprehensive treatment, covering all the needful areas of a woman in menopause, combined with a targeted intervention for those ailments, such as hot flashes, which should be countered immediately as they affect the quality of life most.

Here is Naturando’s response: Donna Sempre Pausa + Donna No Vamp!


Curated by Dr. Chiara Facchinetti


  1. La menopausa prima, durante e dopo”; Ed. il punto d’incontro, Brum B, PavanL.
  2. Metabolic and Epigenetic Regulation by Estrogen in Adipocytes”; Jan-Inge Bjune et. al, 2022, Front Endocrinol.
  3. Estrogen, brain structure, and cognition in postmenopausal women”, Christina P Boyle et. al, 2021, Hum Brain Mapp.
  4. Menopausal hot flashes: mechanisms, endocrinology, treatmen2; Freedman, Robert R., 2014, J Steroid Biochem Mol Biol.